OncoMed presents 1st cancer study data
OncoMed Pharmaceuticals Inc. (NASDAQ:OMED), a clinical-stage biopharmaceutical company focused on discovering and developing novel anti-cancer stem cell and immuno-oncology therapeutics, highlighted data presented during the American Association for Cancer Research (AACR) Annual Meeting related to its clinical trial of tarextumab (anti-Notch2/3, OMP-59R5) and preclinical studies of rosmantuzumab (anti-RSPO3, OMP-131R10) and GITRL-Fc trimer (OMP-OMP-336B11).
- Data from OncoMed’s Phase 1b clinical study of tarextumab in extensive-stage small cell lung cancer show changes in circulating tumor cells (CTCs) appear to correlate with overall survival outcomes. The utility of using CTCs will be evaluated further in OncoMed’s Phase 2 PINNACLE trial of tarextumab.
- In a series of preclinical studies, the combination of anti-RSPO3, now known as rosmantuzumab, with paclitaxel chemotherapy demonstrated synergistic anti-tumor activity in tumors with RSPO3 translocations as well as in tumors with Wnt pathway mutations. These data may be applied in future clinical trials to determine chemotherapy combinations and/or patient selection criteria.
- Another set of preclinical studies identified and characterized biomarkers in tumors and in blood following administration of OncoMed’s GITRL-Fc trimer in syngeneic murine models that may be used in upcoming clinical trials to demonstrate activity. OncoMed is preparing to file an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) during the first half of 2017 for its novel GITRL-Fc trimer immuno-oncology agent.
“OncoMed is pursuing extensive efforts to identify pharmacodynamic markers that deepen our understanding of the mechanisms of action of our agents, as well as predictive biomarkers that may help us identify patients whose tumors are most likely to benefit from our therapeutic candidates,” said Tim Hoey, Ph.D., OncoMed’s Senior Vice President of Cancer Biology and co-Chief Scientific Officer. “The data detailed in these AACR presentations exemplify these translational research efforts and will have direct impact in informing future clinical trial design and analyses for our tarextumab, rosmantuzumab and GITRL-Fc trimer programs.”