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Cancer diagnosed at earlier stages: ASCO

June 3, 2017
Analysis of data available within a national hospital-based registry showed that the diagnosis of stage I disease increased for female breast cancer, colorectal cancer, and lung cancer following implementation of the Affordable Care Act (ACA).
Published Online: June 01, 2017
Published By: Surabhi Dangi-Garimella, PhD

Analysis of data available within the National Cancer Data Base, a national hospital-based registry, showed that the diagnosis of stage I disease increased for female breast cancer, colorectal cancer (CRC), and lung cancer following implementation of the Affordable Care Act (ACA). While early diagnosis of cervical cancer was not statistically significant, diagnosis of stage I prostate cancer saw a drop. The results are scheduled to be presented at the 2017 American Society of Clinical Oncology Annual Meeting.

Inadequate insurance and education have previously been identified as significant determinants of increased screening rates. A 2015 study, published in The American Journal of Managed Care®, found that individuals from lower socioeconomic or uninsured groups are least likely to use preventive screening.

The current study was designed by researchers from the American Cancer Society to identify changes in stage at diagnosis following ACA implementation. The study cohort included nonelderly patients of screening-appropriate age who were diagnosed between 2013 and 2014. The prevalence of of stage I disease was calculated for 5 cancer types, before (2013 Q1 to Q3) and after (2014 Q2 to Q4) the ACA.

Disease-specific distribution was as follows:

  • 121,402 female breast cancer (40 to 64 years)
  • 39,418 CRC (50 to 64 years)
  • 11,190 cervical (21 to 64 years)
  • 41,436 lung (55 to 64 years)
  • 59,210 prostate (50 to 64 years)

The analysis found a statistically significant increase in stage I disease for female breast cancer (47.8% vs 48.9%; prevalence ratio [PR] = 1.02; 95% CI, 1.01-1.03), CRC (22.8% vs 23.7%; PR = 1.04; 95% CI, 1-1.08), and lung cancer (16.6% vs 17.7%; PR = 1.06; 95% CI, 1.02-1.11) in 2014. While cervical cancer saw a nonsignificant shift to stage I disease, (47.2% vs 48.7%; PR = 1.02; 95% CI, 0.98-1.06), the percentage of stage I disease diagnosis for prostate cancer decreased (18.5% vs 17.2%; PR = 0.93; 95% CI, 0.9-0.96) in 2014.

Xuesong Han, PhD, a study co-author, explained during a press cast hosted by ASCO, that the recommendation by the US Preventive Services Task Force (USPSTF) regarding routine prostate cancer screening might have influenced the observed drop in screening rates. USPSTF’s Grade D recommendation for a routine prostate-specific antigen–based screening for prostate cancer has previously been blamed for a reduction in intermediate and high-risk prostate cancer diagnoses.

During the press cast, Han shared detailed analyses based on Medicaid expansion status in US states and concluded that the shift to early stage diagnosis for CRC and lung cancer were mainly seen in Medicaid-expansion states, while the shift observed for female breast cancer was independent of the states’ Medicaid expansion.

http://bit.ly/2sqLDrV

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