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ASCO Saturday recap

June 4, 2017
  • Pregnancy After Breast Cancer Does Not Increase Chance of Recurrence (Abstract LBA10066)
    Findings from a retrospective study of 1,200 women provide reassurance to breast cancer survivors who are contemplating pregnancy. In the study, women who became pregnant after an early breast cancer diagnosis, including those with estrogen receptor (ER)-positive tumors, did not have a higher chance of cancer recurrence and death than those who did not become pregnant. Learn more.
  • Abiraterone Delays Metastatic Prostate Cancer Growth by 18 Months, Extends Survival (Abstract LBA3)
    Adding abiraterone acetate (Zytiga) plus prednisone to standard hormonal therapy for men newly diagnosed with high-risk, metastatic prostate cancer lowers the chance of death by 38%. In a phase III clinical trial of 1,200 men, abiraterone also more than doubled the median time until the cancer worsened, from 14.8 months to 33 months. Learn more.
  • Abiraterone Slows Advanced Prostate Cancer, Helps Patients Live Longer (Abstract LBA5003)
    A clinical trial of nearly 2,000 men shows that adding abiraterone acetate (Zytiga) to a standard initial treatment regimen for high-risk, advanced prostate cancer lowers the relative risk of death by 37%. The 3-year survival rate was 76% with standard therapy alone, but 83% with standard therapy plus abiraterone. This is the largest study of abiraterone as first-line therapy for advanced prostate cancer. Learn more.
  • New Drug Shows Durable Efficacy Across Diverse Pediatric and Adult Cancers (Abstract LBA2501)
    Scientists may have developed the first targeted, oral, tumor-type agnostic therapy – a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients. Response to larotrectinib has been durable, with 79% of responses ongoing 12 months after starting treatment. Learn more.
  • New Technology Dives Deep Into the Cancer Genome (Abstract LBA11516)
    In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high-intensity genomic sequencing approach detected circulating tumor DNA at a high rate. In 89% of patients, at least one genetic change detected in the tumor was also detected in the blood. Overall, 627 (73%) genetic changes found in tumor samples were also found in blood samples with this approach. Learn more.
  • Routine Genomic Testing is Feasible, But Only a Subset of Patients Benefit (Abstract LBA100)
    Genomic testing of tumor samples can enable personalized treatment selection, where targeted treatments are matched to genetic changes in the tumor. Although a growing number of patients with advanced cancers receive some genomic testing, comprehensive genomic testing is not yet routine care. Learn more.

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