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Galapagos’ Ziritaxestat successful in systemic sclerosis study

September 11, 2020

Galapagos (NASDAQ:GLPG) perks up 8% premarket on the heels of positive top line results in the Phase 2a NOVESA trial with investigational ziritaxestat (GLPG1690) in patients with diffuse cutaneous systemic sclerosis (dcSSc), a severe autoimmune disease. The trial enrolled 33 patients.

Ziritaxestat reached the primary endpoint of the study with a statistically significant change from baseline in the modified Rodnan Skin Score (mRSS) at Week 24, of -8.3 (1.2), p=0.0411 vs -5.7 (1.7) for placebo.

GLPG1690 was generally well-tolerated. No deaths were reported.

94% of patients (31 of the 33) who completed the trial continued in the long-term open-label extension trial.

Ziritaxestat is a small molecule, selective autotaxin inhibitor co-developed with Gilead Sciences.

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