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AstraZeneca Lynparza shows positive effect in BRCA-mutated ovarian cancer

September 18, 2020

AstraZeneca (NYSE:AZN) and Merck (NYSE:MRK) announce that LYNPARZA demonstrated a long-term progression-free survival (PFS) benefit versus placebo as a 1st-line maintenance treatment in patients with newly diagnosed, advanced BRCA-mutated (BRCAm) ovarian cancer who had a complete or partial response following platinum-based chemotherapy.

Five-year follow-up data from the Phase III SOLO-1 trial showed LYNPARZA reduced the risk of disease progression or death by 67% (based on a hazard ratio [HR] of 0.33; 95% confidence interval [CI] 0.25-0.43) and improved PFS to a median of 56.0 months versus 13.8 months for placebo.

At five years, 48.3% of patients treated with LYNPARZA remained free from disease progression versus 20.5% on placebo.

The median duration of treatment with LYNPARZA was 24.6 months versus 13.9 months with placebo.

The safety profile of LYNPARZA was consistent with previous observations. 12% of patients on LYNPARZA discontinued treatment due to adverse events.

The results were presented at the 2020 European Society of Medical Oncology (ESMO) virtual congress.

https://seekingalpha.com/news/3615269-astrazenecas-lynparza-shows-positive-effect-in-brca-mutated-ovarian-cancer

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